Gastrointestinal Pathology, An Issue of Gastroenterology Clinics (The Clinics: Internal Medicine)

Due to recent advances in endoscopy and radiology, there is increased recognition of the prevalence and biological characteristics of neoplastic precursor lesions in the GI tract, liver, biliary tract, and pancreas. As a result, there have been major recent developments in the pathologic classification, diagnosis, molecular pathogenesis, natural history and treatment of these lesions. In addition, there are controversial issues with regard to the value of endoscopic screening and surveillance. A close clinician-pathologist interaction is essential in the management of preneoplastic lesions. In this issue the pathology, biological properties, pathogenesis, natural history, and current treatment recommendations of the major preneoplastic and dysplastic precursor lesions of the GI tract, liver, biliary tract and pancreas are reviewed in detail. Wherever possible, accent is given to controversial diagnostic and management-related issues. Each subject matter is written by experts in the field, all of whom have had research experience in their respective areas.